Generated by All in One SEO Pro v5.0.1.1, this is an llms.txt file, used by LLMs to index the site. # Clarenta EXPERTS IN CLINICAL RESEARCH ## Sitemaps - [XML Sitemap](https://www.clarenta.com/sitemap.xml): Contains all public & indexable URLs for this website. ## Posts - [Comac Medical Group Rebrands as Clarenta, Marking a New Chapter as a European Clinical Development Partner](https://www.clarenta.com/comac-medical-group-rebrands-as-clarenta-marking-a-new-chapter-as-a-european-clinical-development-partner/) - Comac Medical Group today announced its rebrand as Clarenta, introducing a new group identity that reflects the evolution of the business. - [Welcoming Christopher Schlebusch as Global Head of Project Management and Clinical Monitoring](https://www.clarenta.com/welcoming-christopher-schlebusch-as-global-head-of-project-management-and-clinical-monitoring/) - Comac Medical is proud to announce the appointment of Christopher Schlebusch as Global Head of Project Management and Clinical Monitoring. - [EdgeCap-backed Comac Medical Group Expands with Acquisition of ILIFE Consulting, a French Early-phase Specialty CRO](https://www.clarenta.com/edgecap-backed-comac-medical-group-expands-with-acquisition-of-ilife-consulting-a-french-early-phase-specialty-cro/) - EdgeCap-backed Comac Medical Group Expands with Acquisition of ILIFE Consulting, a French Early-phase Specialty CRO - [Comac Medical Announces Strategic Leadership Transition](https://www.clarenta.com/leadership-transition/) - Vladimir Goranov and Dr. Rossitsa Vrabevska, MD will jointly lead COMAC MEDICAL into its next phase of growth. - [Comac Medical Unveils New Sustainability Initiatives to Reduce Environmental Impact in Clinical Research](https://www.clarenta.com/comac-medical-unveils-new-sustainability-initiatives-to-reduce-environmental-impact-in-clinical-research/) - [Welcoming Peter Windisch as Chief Operations Officer](https://www.clarenta.com/peter-windisch-chief-operations-officer/) - [Comac Medical's 2024 Event Highlights & 2025 Roadmap](https://www.clarenta.com/comac-medicals-2024-event-highlights-and-2025-roadmap/) - [Comac Medical Laboratory Achieves GcLP Accreditation](https://www.clarenta.com/comac-medical-laboratory-achieves-gclp-accreditation/) - [Welcoming Christian Buhlmann as Chief Commercial Officer (CCO)](https://www.clarenta.com/welcoming-christian-buhlmann-as-chief-commercial-officer-cco/) - [Comac Medical Earns EcoVadis Badge for Sustainability](https://www.clarenta.com/comac-medical-earns-ecovadis-badge-for-sustainability/) - [Leading Biometrics Expert at Comac Medical Supports Breakthrough UTI Study](https://www.clarenta.com/leading-biometrics-expert-at-comac-medical-supports-breakthrough-uti-study/) - [Comac Medical Announces New Leadership Appointments and International Expansion](https://www.clarenta.com/comac-medical-announces-new-leadership-appointments-and-international-expansion/) - Comac Medical, a leading full-service CRO, announced on April 28, 2025, the appointment of a new CEO and Board Chair and the launch of an international expansion initiative. - [Celebrating 20 Years of Excellence at Comac Medical’s North Macedonia Office](https://www.clarenta.com/celebrating-20-years-of-excellence-at-comac-medical-s-north-macedonia-office/) - This May, Comac Medical proudly celebrates the 20th anniversary of our North Macedonia office. - [Welcoming Brian Swindley as Global Head of Project Management  ](https://www.clarenta.com/welcoming-brian-swindley-as-global-head-of-project-management/) - Comac Medical proudly welcomes Brian Swindley as our new Global Head of Project Management. Brian will officially join on the 2nd of June, 2025. - [Comac Medical’s Head of Statistics Supports New Study on Autoimmune Markers in Addison’s Disease ](https://www.clarenta.com/comac-medical-s-head-of-statistics-supports-new-study-on-autoimmune-markers-in-addison-s-disease/) - Comac Medical is pleased to announce the publication of a new scientific article, co-authored by Professor Krassimir Kalinov, Head of the Statistics Team at Comac Medical. - [Welcoming Steve Angus as Chief Financial Officer (CFO)](https://www.clarenta.com/welcoming-steve-angus-as-chief-financial-officer-cfo/) - Comac Medical is pleased to announce that Steve Angus will be joining as our new Chief Financial Officer (CFO), effective September 1st. Steve brings with him more than 20 years of experience in financial leadership. - [Recycle at HQ: Together We’re Making Our Office More Sustainable](https://www.clarenta.com/recycle-at-hq-together-were-making-our-office-more-sustainable/) - [Chris Smyth on Leadership & Empowered Teams: Inside the Mind of Our New CEO](https://www.clarenta.com/chris-smyth-on-leadership-and-empowered-teams-inside-the-mind-of-our-new-ceo/) - We are pleased to introduce Chris Smyth, Group CEO of Comac Medical, through this three-part in-depth interview series. Watch the full videos and read more. - [EdgeCap Acquires Majority Stake in Comac Medical, Founder & Management Retain Significant Minority Interest](https://www.clarenta.com/edgecap-acquires-majority-stake-in-comac-medical-founder-and-management-retain-significant-minority-interest/) ## Pages - [Home](https://www.clarenta.com/) - Comac Medical Group is now Clarenta. The European CRO guiding biotech and pharmaceutical teams from early phase strategy through clinical trial delivery. - [Privacy Policy](https://www.clarenta.com/privacy-policy/) - Read Clarenta’s Privacy Policy to understand how we collect, use, protect and manage personal data when you visit and interact with our website. - [CMC Development](https://www.clarenta.com/solutions/drug-development-consulting/cmc-development/) - Build a practical CMC strategy for formulation, analytical development, manufacturing, stability, CDMO management and regulatory readiness with Clarenta. - [Drug Development Consulting](https://www.clarenta.com/solutions/drug-development-consulting/) - Plan the path to the clinic with a drug development strategy, pharmacology, toxicology, study planning, and specialist provider management. - [Our Team](https://www.clarenta.com/about-us/our-team/) - Discover Clarenta's skilled team of clinical research professionals with over 27 years of experience, dedicated to advancing drug development. - [About Us](https://www.clarenta.com/about-us/) - Discover Clarenta’s story, mission, vision and values, and how our approach to partnership helps sponsors navigate clinical development with confidence. - [Clinical Research Consulting](https://www.clarenta.com/services/clinical-research-consulting/) - Turn complex questions into a clear development path with scientific, regulatory and operational guidance from Clarenta’s consultants. - [Services](https://www.clarenta.com/services/) - Discover Clarenta’s clinical research consulting, full-service CRO capabilities and Phase I Unit, bringing clarity and control to clinical development. - [The Clarenta Story](https://www.clarenta.com/about-us/the-clarenta-story/) - Explore Clarenta’s story, from the foundations of Comac Medical and ILIFE Consulting to 29 years of experience supporting clinical development across Europe. - [Regulatory Affairs](https://www.clarenta.com/solutions/drug-development-consulting/regulatory-affairs/) - Turn early-stage drug development and CMC evidence into a clear regulatory strategy for agency interactions and clinical trial submissions with Clarenta. - [Privacy Notice for Investigators](https://www.clarenta.com/privacy-notice-for-clinical-research-sites-and-investigators/) - Review our Privacy Notice for clinical research sites, investigators, and partners. Learn how we handle your data in recruitment activities. - [Full-service CRO](https://www.clarenta.com/services/full-service-cro/) - Partner with a European full-service CRO for connected clinical trial strategy, regulatory support, operations, data, safety, and medical oversight. - [Small & Mid-sized Pharma](https://www.clarenta.com/about-us/our-clients/small-mid-sized-pharma/) - Discover adaptable clinical development and trial delivery support for small and mid-sized pharma companies from an experienced European CRO partner. - [Biotech Companies](https://www.clarenta.com/about-us/our-clients/biotech-companies/) - Explore flexible clinical development support for biotech companies, combining experienced guidance, regulatory strategy and clinical delivery across Europe. - [Client Testimonials](https://www.clarenta.com/clinical-excellence/client-testimonials/) - Hear from biotech and pharmaceutical teams about Clarenta’s clear communication, responsive support and reliable clinical trial delivery. - [Early Phase Clinical Development](https://www.clarenta.com/solutions/early-phase-clinical-development/) - Move from first-in-human studies to early proof of concept with an integrated early-phase CRO combining strategy, clinical pharmacology and European delivery. - [CRO Partners](https://www.clarenta.com/about-us/our-clients/cro-partners/) - Extend your clinical research capabilities through a trusted CRO partnership, with local expertise, operational support and trial delivery across Europe. - [Contact Us](https://www.clarenta.com/about-us/contact-us/) - Contact Clarenta for clinical development support, career opportunities, site and investigator partnerships, event requests or vendor enquiries. - [Phase I Unit](https://www.clarenta.com/services/phase-i-unit/) - Conduct early-phase clinical trials in healthy volunteers and patients at Clarenta’s Phase I Unit in Sofia, supported by connected clinical, regulatory and operational expertise. - [Events](https://www.clarenta.com/events/) - Discover upcoming medical conferences and events. Join the Clarenta team at key clinical trial networking opportunities. - [Clinical Excellence](https://www.clarenta.com/clinical-excellence/) - Explore Clarenta’s therapeutic expertise, clinical trial case studies and client testimonials, backed by 29 years of clinical research experience. - [Proof-of-Concept (PoC) Studies](https://www.clarenta.com/solutions/early-phase-clinical-development/proof-of-concept-studies/) - Plan and deliver Phase Ib and Phase IIa proof-of-concept clinical trials with connected scientific strategy, patient feasibility and operational support across Europe. - [First-in-Human (FIH) Studies](https://www.clarenta.com/solutions/early-phase-clinical-development/first-in-human-cro/) - Partner with a First-in-Human CRO that connects FIH strategy, SAD/MAD studies, dose escalation, safety oversight, and Phase I execution. - [Early Phase Oncology Trials](https://www.clarenta.com/solutions/early-phase-clinical-development/early-phase-oncology-trials/) - Plan and deliver early-phase oncology trials across Europe with specialist CRO support for study design, dose escalation, patient access and adaptive execution. - [PK & Clinical Pharmacology Studies](https://www.clarenta.com/solutions/early-phase-clinical-development/pk-clinical-pharmacology-studies/) - Plan and deliver human PK and clinical pharmacology studies with connected scientific, regulatory, and operational support across Europe. - [Careers](https://www.clarenta.com/about-us/careers/) - Find career opportunities at Clarenta, where employees are valued as our greatest asset. Join a dynamic team now! - [Clinical Trial Case Studies](https://www.clarenta.com/clinical-excellence/clinical-trial-case-studies/) - Explore Clarenta’s clinical trial case studies across early-phase oncology, clinical pharmacology, Proof-of-Concept studies, recruitment and clinical operations. - [Certifications](https://www.clarenta.com/clinical-excellence/certifications/) - Explore our medical and regulatory certifications, ensuring compliance and excellence in clinical trials. We are a trusted SMO & CRO company. - [Therapeutic Areas](https://www.clarenta.com/clinical-excellence/therapeutic-areas/) - Explore Clarenta’s experience across oncology, rare diseases, neurology, respiratory diseases, dermatology, gastroenterology and other therapeutic areas. - [First-in-Human Immuno-Oncology Trial](https://www.clarenta.com/clinical-excellence/clinical-trial-case-studies/first-in-human-immuno-oncology-trial/) - See how Clarenta provided embedded clinical operations leadership for a first-in-human oncology trial across Europe and the US, recruiting 262 patients. - [Early-Phase Clinical Operations Gap Analysis](https://www.clarenta.com/clinical-excellence/clinical-trial-case-studies/early-phase-clinical-operations-gap-analysis/) - See how Clarenta’s gap analysis identified recruitment and operational barriers in a Phase I/II glioblastoma study and informed corrective actions. - [Phase II Asthma Proof-of-Concept Trial](https://www.clarenta.com/clinical-excellence/clinical-trial-case-studies/phase-ii-asthma-proof-of-concept-trial/) - See how Clarenta supported a Phase II asthma Proof-of-Concept study, enrolling 48 participants and helping the leading site exceed its target by 93%. - [Phase I Oncology Pharmacokinetic Study](https://www.clarenta.com/clinical-excellence/clinical-trial-case-studies/phase-i-oncology-pharmacokinetic-study/) - See how Clarenta supported a Phase I oncology study in Bulgaria, recruiting 36 patients in two months while managing intensive pharmacokinetic procedures. - [Phase I Atopic Dermatitis PK Study](https://www.clarenta.com/clinical-excellence/clinical-trial-case-studies/phase-i-atopic-dermatitis-pk-study/) - See how Clarenta recruited the full population for a Phase I atopic dermatitis study in four months, achieving a 92% screen-to-enrollment rate. - [Our Clients](https://www.clarenta.com/about-us/our-clients/) - See how Clarenta works alongside biotech, pharmaceutical and CRO teams, bringing strategic guidance, clarity and reliable clinical trial delivery. - [FAQs](https://www.clarenta.com/faqs/) - Find answers to common questions about Clarenta, our rebrand from Comac Medical, what has changed and what remains the same for our clients and partners. - [Sponsor Enquiries](https://www.clarenta.com/about-us/contact-us/sponsor-enquiries/) - Planning a clinical trial or looking for development support? Tell us about your programme and connect with the Clarenta team. - [Vendor Inquiries](https://www.clarenta.com/about-us/contact-us/vendor-inquiries/) - Does your organisation provide services that could support our work? Introduce your capabilities and submit a vendor enquiry to Clarenta. - [Event Inquiries](https://www.clarenta.com/about-us/contact-us/event-inquiries/) - Would you like Clarenta to speak, participate or collaborate at your event? Share the details with our team for consideration. - [Investigators](https://www.clarenta.com/about-us/contact-us/investigators/) - Fill out the form to join Clarenta as an Investigator. Help advance medical research and clinical trials. Start your journey today! - [Site Partnerships](https://www.clarenta.com/about-us/contact-us/site-partnerships/) - Register your hospital, medical centre or research site to be considered for current and future clinical trial opportunities with Clarenta. - [Insights](https://www.clarenta.com/insights/) - Stay informed with the latest Clarenta news and events. Visit our Newsroom for updates on our clinical trials, achievements, and upcoming events - [Solutions](https://www.clarenta.com/solutions/) - Explore Clarenta’s non-clinical and early-phase development solutions, designed to bring clarity to critical decisions and guide your next stage. - [Cookies Policy](https://www.clarenta.com/cookies-policy/) - Learn about Clarenta's Cookies Policy, how we use cookies to enhance your experience, and your options for managing them. ## Events - [ESMO Congress 2026 ](https://www.clarenta.com/event/esmo-congress-2026/) - Meet Clarenta at ESMO Congress 2026 in Madrid, 23–27 October, to discuss oncology clinical development, feasibility and trial delivery across Europe. - [BIO-Europe Fall 2026 ](https://www.clarenta.com/event/bio-europe-fall-2026/) - Meet Clarenta at BIO-Europe Fall 2026 in Cologne, 9–11 November. Visit booth 8-38 to discuss clinical development and European trial delivery. - [OCT DACH 2026 ](https://www.clarenta.com/event/oct-dach-2026/) - Meet Clarenta at OCT DACH 2026 in Basel, 3–4 November. Visit booth 18 to discuss feasibility, clinical operations and smarter trial planning. - [OCT New England 2026](https://www.clarenta.com/event/oct-new-england-2026/) - Meet Clarenta at OCT New England 2026, 27–28 October. Visit booth 18 to discuss European feasibility and international clinical trial delivery. - [Biotech Showcase 2026](https://www.clarenta.com/event/biotech-showcase-2026/) - Comac Medical is excited to announce our participation in Biotech Showcase 2026, taking place on January 12–14, 2026, in San Francisco, USA. - [EUCROF 2026](https://www.clarenta.com/event/eucrof-2026/) - Comac Medical at EUCROF2026: CEO Chris Smyth speaks in Plenary 3 on the EU Biotech Act, life sciences strategy, and regulatory evolution from a CRO perspective. - [OCT West Coast 2026](https://www.clarenta.com/event/oct-west-coast-2026/) - Comac Medical is pleased to announce our participation in OCT West Coast 2026, taking place in San Francisco. - [BIO CHINA 2026](https://www.clarenta.com/event/bio-china-2026/) - [Bio Europe Spring 2026](https://www.clarenta.com/event/bio-europe-spring-2026/) - Meet Comac Medical at BIO-Europe Spring 2026 in Lisbon, March 23–25. Visit Booth #61 to connect with our experts and explore clinical trial solutions. - [CMO Summit 360°](https://www.clarenta.com/event/cmo-summit-360/) - Comac Medical is pleased to announce our participation in the CMO Summit 360° 2026, taking place April 13–14, 2026, in Boston, USA. - [Bio€quity Europe 2026](https://www.clarenta.com/event/bioequity-europe-2026/) - [OCT East Coast 2026](https://www.clarenta.com/event/oct-east-coast-2026/) - [Swiss Biotech Day 2026](https://www.clarenta.com/event/swiss-biotech-day-2026/) - [BioPharma Clinical Trials Nexus 2026](https://www.clarenta.com/event/biopharma-clinical-trials-nexus-2026/) - [OCT Europe 2026](https://www.clarenta.com/event/oct-europe-2026/) - [OCT & Ireland 2026](https://www.clarenta.com/event/oct-ireland-2026/) ## Articles - [Effective Strategies for Clinical Trial Rescue Studies](https://www.clarenta.com/article/effective-strategies-for-clinical-trial-rescue-studies/) - Explore strategies for clinical trial rescue, from low enrollment to data management, and learn how to choose the right CRO. See how Comac Medical can assist. - [Clinical Trial Feasibility Assessment: A Critical Step for Biotech Success](https://www.clarenta.com/article/clinical-trial-feasibility-assessment-a-critical-step-for-biotech-success/) - Discover the importance of clinical trial feasibility assessments for biotech companies. Learn how select the right CRO, get some actionable tips on feasibility success. - [Benefits of Conducting Clinical Trials in Central and Eastern Europe (CEE)](https://www.clarenta.com/article/benefits-of-conducting-clinical-trials-in-central-and-eastern-europe-cee/) - Discover the advantages of conducting clinical trials in CEE—from diverse patient access and lower costs to EU-aligned regulations and expert investigators. - [Rare Disease Clinical Trials: Challenges & Regulatory Opportunities](https://www.clarenta.com/article/rare-disease-clinical-trials-challenges-regulatory-opportunities/) - With only 5% of rare diseases having treatments, this article explores rare disease clinical trials challenges, regulatory solutions, and a path toward patient hope. - [The Rising Demand for Dermatology Clinical Trials & Key Challenges](https://www.clarenta.com/article/the-rising-demand-for-dermatology-clinical-trials-and-key-challenges/) - Discover why dermatology clinical trials are rising in demand, the challenges they face, and how Comac Medical supports innovation in skin disease research. - [Understanding ICH GCP E6(R3) Guidelines: What’s New and Why It Matters](https://www.clarenta.com/article/understanding-ich-gcp-e6-r3-guidelines-what-s-new-and-why-it-matters/) - As clinical trials evolve, the new ICH GCP E6(R3) guidelines redefine global standards. Discover what’s changing—and why it matters for the future of research. - [Patient Recruitment in Clinical Trials: Comprehensive Guide to Problems & Solutions ](https://www.clarenta.com/article/patient-recruitment-in-clinical-trials-comprehensive-guide-to-problems-and-solutions/) - Struggling with patient recruitment in clinical trials? This guide reveals the top challenges and actionable strategies to optimize enrollment and retention. - [Clinical Trial Protocol Development Best Practices for Success](https://www.clarenta.com/article/clinical-trial-protocol-development-best-practices-for-success/) - Effective clinical trial protocol development reduces delays and boosts study success. Learn expert-backed best practices and pitfalls to avoid. - [Exploring the Key Types of Clinical Trial Designs in Modern Research](https://www.clarenta.com/article/exploring-the-key-types-of-clinical-trial-designs-in-modern-research/) - From parallel and crossover to adaptive, basket, and pragmatic—learn about key types of clinical trial designs and their role in study success. - [Navigating Clinical Trial Supply Management: Challenges, Trends & Smarter Strategies ](https://www.clarenta.com/article/navigating-clinical-trial-supply-management-challenges-trends-and-smarter-strategies/) - Learn more about clinical trial supply management challenges, emerging trends, and proven strategies to ensure successful, compliant, and efficient trial delivery. - [Seasonal Health Through the Lens of Modern Clinical Research](https://www.clarenta.com/article/seasonal-health-through-the-lens-of-modern-clinical-research/) - Explore how clinical research is advancing treatments for summer-related illnesses like heat stress, allergies, and mosquito-borne diseases. - [The Biotech CRO Checklist: How to Choose the Right Partner for Your Clinical Trials](https://www.clarenta.com/article/the-biotech-cro-checklist-how-to-choose-the-right-partner-for-your-clinical-trials/) - Searching for the right biotech CRO? Discover how to choose a clinical research organization that supports your biotech trials, from early development to FDA approval.